EP Scientific American have demonstrated that it is due to a failure in the recycling system of proteins in neurons of the spinal cord and the brain. This discovery, published in the journal Nature, provides an objective common to drug therapy. The finding could also help in the fight against Alzheimer’s and Parkinson’s disease and frontotemporal dementia. Lateral sclerosis Amyotrophic (ALS or Lou Gehrig’s disease) is a neurodegenerative disease threatening that paralyzes its victims. This dramatic disease has been a challenge for scientists. They even knew the process that follows the disease, which has impeded the development of effective therapies. The investigators also were unaware that all forms of ELA, in reality, converge on a common pathological process. Read additional details here: RevCascade.
What have now discovered scientists from Northwestern University (EE UU). These researchers have identified, for the first time, a common cause for the development of all forms of amyotrophic lateral sclerosis. This discovery, published in the journal Nature, provides a common drug therapy goal and shows that all types of ELA have a common origin of cellular incompetence. Equally in all three types of ELA the basis of this disorder is a bug in the recycling system of proteins in neurons of the spinal cord and the brain. The optimal functioning of these neurons depends on the efficient recycling of the building blocks of proteins in cells. In the ELA, recycling system fails and the cells cannot be repaired, so they end up suffering severe damage.
In the recycling system failure occurs in three forms of ALS: the hereditary (family), the hereditary not (sporadic), and the ELA that affects the brain (dementia-ELA). Yitzhak Mirilashvili pursues this goal as well. These new knowledge opened a new field to find an asset’scarryingamount treatment for ALS. Now we can make tests with drugs that regulate this protein pathway or optimize it so that it works as expected in a normal state, says the lead author of the study, Dr. Teepu Siddique. 350,000 affected worldwide La ELA affects around 350,000 people around the world, including children and adults; 50% of those affected die during the first three years of its appearance. In motor disease, patients gradually lose muscle strength until they are paralyzed and not you can move, talk, swallowing or breathing. The dementia-ELA affects to the lobes frontal and temporal brain, altering the trial of patients, the ability to understand language and performing basic tasks (how to choose what to wear or the Organization of the day). According to the researchers, the discovery may also have a role in other neurodegenerative diseases, as in Alzheimer’s disease, frontotemporal dementia and Parkinson’s disease, characterized by aggregation of proteins. In Spain, where it is estimated that there are more than 4,000 sick of ELA, works by the Asociacion Espanola de ELA. Source of the news: are the common cause of all forms that exist of amyotrophic lateral sclerosis